일송생명과학연구소

Lab of Prion Diseases and Neurotropic Viruses Research

Yong-Sun Kim, M.D., Ph.D.

Research Interests

1. The pathogenic mechanisms of neurodegeneration in Prion diseases 

2. Diagnosis of human Prion diseases

3. The study on role of endogenous retroviruses in aging and neurodegenerative disorders

Publications

1. Cha S, Sin MJ, Kim MJ, Kim HJ, Kim YS, Choi EK, Kim MY. Involvement of Cellular Prion Protein in Invasion and Metastasis of Lung Cancer by Inducing Treg Cell Development. Biomolecules. 2021 Feb 15;11(2):285. doi: 10.3390/biom11020285.

2. Jang B, Kim MJ, Lee YJ, Ishigami A, Kim YS, Choi EK. Vimentin citrullination probed by a novel monoclonal antibody serves as a specific indicator for reactive astrocytes in neurodegeneration. Neuropathol Appl Neurobiol. 2020 Dec;46(7):751-769. doi: 10.1111/nan.12620.

3. Jin HT, Park SJ, Choi EK, Kim YS. The frequency of Merkel cell polyomavirus in whole blood from immunocompetent and immunosuppressed patients with kidney disease and healthy donors. Microb Pathog. 2019 Jun;131:75-80. doi: 10.1016/j.micpath.2019.03.020.

4. Park JH, Choi YG, Park SJ, Choi HS, Choi EK, Kim YS. Ultra-efficient Amplification of Abnormal Prion Protein by Modified Protein Misfolding Cyclic Amplification with Electric Current. Mol Neurobiol. 2018 Feb;55(2):1630-1638. doi: 10.1007/s12035-017-0431-8.

5. Wang F, Wang X, Orrú CD, Groveman BR, Surewicz K, Abskharon R, Imamura M, Yokoyama T, Kim YS, Vander Stel KJ, Sinniah K, Priola SA, Surewicz WK, Caughey B, Ma J. Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity. PLoS Pathog. 2017 Jul 12;13(7):e1006491. doi: 10.1371/journal.ppat.1006491.