일송생명과학연구소

Lab of Molecular Neurogenetics

Young Ho Koh, Ph.D. (Head of Department of Biomedical Gerontology)

Research Interests

1. Drosophila models of complex neurological disorders in human

2. Investigating in vivo functions of highly conserved synaptic molecular components at molecular levels using Type 1 glutamatergic Drosophila larval synapses as a model

3. Identifying and developing pathogen specific makers for rapid diagnosis of diseases or pathogens

4. Development of treatments for Alzheimer’s disease and Parkinson disease by enhancing mitochondria functions in the brain

Publications

1. Mai LX, Kang SK, Jo YY, Nguyen P, Kim AY, Kim KY, Kim NS, Koh YH. An Alkaline Protease-Digestion of Silkworm Powder Enhances Its Effects Over Healthspan, Autophagy, and Mitochondria Function in a Rotenone-Induced Drosophila Model. Front Nutr. 2022 Jun 16;9:808295. doi: 10.3389/fnut.2022.808295.

2. Osabutey AF, Seo BY, Kim AY, Ha TAT, Jung J, Goergen G, Owusu EO, Lee GS, Koh YH. Identification of a fall armyworm (Spodoptera frugiperda)-specific gene and development of a rapid and sensitive loop-mediated isothermal amplification assay. Sci Rep. 2022 Jan 18;12(1):874. doi: 10.1038/s41598-022-04871-2.

3. Nguyen P, Kim KY, Kim AY, Kang S, Osabutey AF, Jin H, Guo Y, Park H, Suh JW, Koh YH. The additive memory and healthspan enhancement effects by the combined treatment of mature silkworm powders and Korean angelica extracts. J Ethnopharmacol. 2021 Dec 5;281:114520. doi: 10.1016/j.jep.2021.114520.

4. Nguyen P, Kim KY, Kim AY, Choi BH, Osabutey AF, Park YH, Lee HT, Ji SD, Koh YH. Mature silkworm powders ameliorated scopolamine-induced amnesia by enhancing mitochondrial functions in the brains of mice. J Funct Foods. 2020 Apr;67(2020):103886. doi: 10.1016/j.jff.2020.103886.

5. Hur JH, Lee SH, Kim AY, Koh YH. Regulation of synaptic architecture and synaptic vesicle pools by Nervous wreck at Drosophila Type 1b glutamatergic synapses. Exp Mol Med. 2018 Mar 23;50(3):e462. doi: 10.1038/emm.2017.303.