일송생명과학연구소

Lab of Cell Biology

Dongchul Kang, Ph.D.

Research Interests

1. Differentiation therapy of cancer: to study mechanism of cancer cell differentiation and senescence

2. Genomic/post-genomic interpretation of differential drug response of cancer cells

3. Cell Immunity: at cellular level, to study diverse aspects of the damage control mechanism to various cytotoxic agents in normal and cancer cells, especially focusing on initial stage of signal transduction

Publications

1. To HTN, Park JH, Kim JW, Kang D. Delta/Notch-like Epidermal Growth Factor-Related Receptor (DNER), a Potential Prognostic Marker of Gastric Cancer Regulates Cell Survival and Cell Cycle Progression. Int J Mol Sci. 2023 Jun 13;24(12):10077. doi: 10.3390/ijms241210077.

2. To HTN, Le QA, Bui HTT, Park JH, Kang D. Modulation of Spheroid Forming Capacity and TRAIL Sensitivity by KLF4 and Nanog in Gastric Cancer Cells. Curr Issues Mol Biol. 2022 Dec 30;45(1):233-248. doi: 10.3390/cimb45010018.

3. Cho HY, Lee S, Park JH, Kwak YH, Kweon H, Kang D. Competitive Hybridization of a Microarray Identifies CMKLR1 as an Up-Regulated Gene in Human Bone Marrow-Derived Mesenchymal Stem Cells Compared to Human Embryonic Fibroblasts. Curr Issues Mol Biol. 2022 Mar 28;44(4):1497-1512. doi: 10.3390/cimb44040102.

4. Dubon M, Lee S, Park JH, Lee JY, Kang D. The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC). Int J Med Sci. 2021 Feb 4;18(7):1580-1591. doi: 10.7150/ijms.53650.

5. Kim JG, Mahmud S, Min JK, Lee YB, Kim H, Kang DC, Park HS, Seong J, Park JB. RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to β-catenin and contributes transcriptional regulation of vimentin upon Wnt3A. Redox Biol. 2021 Apr;40:101842. doi: 10.1016/j.redox.2020.101842.

6. Bui HTT, Le NH, Le QA, Kim SE, Lee S, Kang D. Synergistic apoptosis of human gastric cancer cells by bortezomib and TRAIL. Int J Med Sci. 2019 Sep 20;16(11):1412-1423. doi: 10.7150/ijms.34398.

7. Lee S, Le NH, Kang D. Melatonin alleviates oxidative stress-inhibited osteogenesis of human bone marrow-derived mesenchymal stem cells through AMPK activation. Int J Med Sci. 2018 Jun 23;15(10):1083-1091. doi: 10.7150/ijms.26314.