일송생명과학연구소

Lab of Aging & Neurodegenerative Diseases

Eun-Kyoung Choi, Ph.D. (Director & Professor)

Research Interests

1. Molecular and cellular mechanisms of brain aging and neurodegeneration 

2. Functional analysis of Peptidylarginine deiminase and discovery of regulatory molecules

3. Development of antibodies and diagnostic markers related to the protein citrullinome

4. Pathogenesis and therapeutic development for prion diseases

Selected Publications

1. DB Kim, et al. A mouse xenograft long-term replication yields a SARS-CoV-2 Delta mutant with increased lethality. J Med Virol. 96(2):e29459, 2024.

2. HT Jin, et al. Human papillomavirus and Merkel cell polyomavirus in Korean patients with nonsmall cell lung cancer: Evaluation and genetic variability of the noncoding control. J Med Virol. 96(8):e29880, 2024. 

3. YG Choi, et al. Radotinib decreases prion propagation and prolongs survival times in models of prion disease. Int J Mol Sci. 24:12241, 2023.

4. MJ Kim, et al., Impairment of neuronal mitochondrial quality control in prion-induced neurodegeneration. Cells. 11(17):2744, 2022.

5. S Cha, et al. Involvement of Cellular Prion Protein in Invasion and Metastasis of Lung Cancer by Inducing Treg Cell Development. Biomolecules, 11(2):285, 2021.

6. SJ Park, et al. Establishment of Method for the Determination of Aggregated α-Synuclein in DLB Patient Using RT-QuIC Assay. Protein Pept Lett, 28(1):115-120, 2021.

7. B Jang, et al. Vimentin citrullination probed by a novel monoclonal antibody serves as a specific indicator for reactive astrocytes in neurodegeneration. Neuropathol Appl Neurobiol, 46(7):751-769, 2020.

8. HJ Kim, et al. RhoA/ROCK regulates prion pathogenesis by controlling connexin 43 activity. Int J Mol Sci. 21(4):1255, 2020.

9. SE Kim, et al. Accumulation of citrullinated glial fibrillary acidic protein in a mouse model of bile duct ligation-induced hepatic fibrosis. PLoS One. 13(8):e0201744, 2018.

10. B Jang, et al. Myelin Basic Protein Citrullination, a Hallmark of Central Nervous System Demyelination, Assessed by Novel Monoclonal Antibodies in Prion Diseases. Mol Neurobiol. 55:3172-3184, 2018.

11. B Jang, et al. The peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells. Int J Mol Sci. 18(11). pii: E2258, 2017.

12. HJ Kim, et al. Regulation of RhoA activity by the cellular prion protein. Cell Death Dis. 8(3): e2668, 2017 

13. H Masutomi, et al. Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells. J Neurosci Res. 97(7):1503-1512, 2017.

14. A Ishigami, et al. Mass spectrometric identification of citrullination sites and immunohistochemical detection of citrullinated glial fibrillary acidic protein in Alzheimer's disease brains. J Neurosci Res 93:1664-1674, 2015.

15. A Ishigami, et al. Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis. Mod Rheumatol. 23(4):794-803, 2013.

16. YJ Lee, et al. Complete genome sequences of new xenotropic murine leukemia viruses from the senescence-accelerated mouse (SAM): molecular and phylogenetic analyses. PLoS One 8(2):e55669, 2013.

17. B Jang, et al. Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases. Biochem J. 445:183-192, 2012.

18. B Jang, et al. Subcellular localization of peptidylarginine deiminase 2 and citrullinated proteins in brains of scrapie-infected mice: Nuclear localization of PAD2 and membrane fraction-enriched citrullinated proteins. J Neuropathol Exp Neurol. 70(2):116-124, 2011.

19. B Jang, et al. Involvement of peptidylarginine deiminase-mediated post-translational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease. Acta Neuropathol. 119:199-210, 2010.

20. B Jang, et al. Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice. A possible role in pathogenesis. Am. J. Pathol. 173: 1129-1142, 2008.